Jewish American Heritage Month

Posted By richards on February 6, 2015

Jewish Genetics: Abstracts and Summaries Part 3: Jewish Genetic Diseases and Disease Protections Last Update: November 19, 2014 Studies on Jewish genetic diseases (with special attention on studies that help to confirm Jewish origins, relationships, and migrations)

Laurie J. Ozelius, Geetha Senthil, R. Saunders-Pullman, E. Ohmann, et al., "LRRK2 G2019S as a Cause of Parkinson's Disease in Ashkenazi Jews." The New England Journal of Medicine 354:4 (January 26, 2006): 424-425. Excerpts:

Cyrus P. Zabetian, Carolyn M. Hutter, Dora Yearout, Alexis N. Lopez, Stewart A. Factor, Alida Griffith, Berta C. Leis, Thomas D. Bird, John G. Nutt, Donald S. Higgins, John W. Roberts, Denise M. Kay, Karen L. Edwards, Ali Samii, and Haydeh Payami. "LRRK2 G2019S in Families with Parkinson Disease Who Originated from Europe and the Middle East: Evidence of Two Distinct Founding Events Beginning Two Millennia Ago." American Journal of Human Genetics 79 (2006): 752-758. Abstract:

Talia Bloch. "One Big, Happy Family: Litvaks and Galitzianers, Lay Down Your Arms; Science Finds Unity in the Jewish Gene Pool." The Forward (August 22, 2007). Excerpt:

M. M. Carrasquillo, J. Zlotogora, S. Barges, and Aravinda Chakravarti, "Two different connexin 26 mutations in an inbred kindred segregation non-syndromic recessive deafness: implications for genetic studies in isolated populations." Human Molecular Genetics 6(12) (November 1997): 2163-2172. This study examines DFNBs that cause non-syndromic recessive deafness (NSRD), with particular attention to human chromosome 13q11 (DFNB1). It was discovered that some Jews, Palestinian and Israeli Arabs, and other Mediterranean peoples possess the DFNB1 genetic mutation.

George E. Ehrlich, M.D. "Genetics of Familial Mediterranean Fever and Its Implications." Annals of Internal Medicine 129 (October 1, 1998): 581-582. Excerpts:

Shlomit Eisenberg, Ivona Aksentijevich, Zuoming Deng, Daniel L. Kastner, and Yaacov Matzner. "Diagnosis of Familial Mediterranean Fever by a Molecular Genetics Method." Annals of Internal Medicine 129:7 (October 1, 1998): 539-542. Excerpt:

N. Stoffman, N. Magal, T. Shohat, M. Shohat, R. Lotan, S. Koman, A. Oron, Y. Danon, G. J. Halpern, Y. Lifshitz. "Higher than expected carrier rates for familial Mediterranean fever in various Jewish ethnic groups." European Journal of Human Genetics 8(4) (April 2000): 307-310.

The International FMF Consortium. "Ancient Missense Mutations in a New Member of the RoRet Gene Family are Likely to Cause Familial Mediterranean Fever." Cell 90 (August 22, 1997): 797-807. Abstract excerpt:

Nicholas Wade. "Gene From Mideast Ancestor May Link 4 Disparate Peoples" The New York Times (August 22, 1997): A19. Excerpts:

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Jewish Genetics, Part 3: Jewish Genetic Diseases ...

Category: Ashkenazi
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